Allergic Granulomatosis And Angiitis (Churg-Strauss Syndrome)

Allergic granulomatosis and angiitis is also known as Churg-Strauss syndrome and is one form of vasculitis. These diseases involve the inflammation of blood vessels and usually occur in those who have a history of allergy or asthma.

The causes of Churg-Strauss syndrome is not known, and the condition itself is rare. It involves an over-activation of the immune system in those who have asthma. It has been reported that the condition is linked to certain asthma medications, though this is not entirely clear.

Symptoms of Churg-Strauss Syndrome

There are several symptoms including weight loss, sinus inflammation, fever and fatigue. The asthma itself may improve though a cough may develop as well as chest pain and shortness of break due to the lings being affected with vasculitis.

When there is inflammation of the abdomen this may cause stomach pain or diarrhea as well as the bladder becoming inflamed. Seizures can also occur if the brain becomes affected.

Treatment of Churg-Strauss Syndrome

The treatment is directed at reducing the inflammation of the blood vessels at the same time as suppressing the immune system. This includes high doses of cortisone-related medication as well as cyclophosphamide to suppress the immune system. The latter may be given for a year or longer, though recent studies suggest it may work just as well if given for 6 to 12 months.

This syndrome can be fatal, and therefore it is extremely dangerous if left untreated. The organs that are affected will be threatened, so aggressive treatment and monitoring are both required. This can lead to remission of the disease.